Playing Alice effectively requires a balance of aggression and careful positioning, reflecting her moderately high difficulty. In the early game, focus on farming and absorbing blood orbs from dying minions. This is crucial for stacking her permanent Max HP and gaining additional stat upgrades from her passive, which are vital for her late-game power spike. Use Flowing Blood (Skill 1) for poking enemies and clearing minion waves, but be mindful of your mana.
As the game progresses into the mid-game, look for opportunities to engage. Alice's high magical offense allows her to deal significant damage. Use the two-part cast of Flowing Blood to initiate on isolated targets or to reposition quickly. Follow up with Blood Awe (Skill 2) to immobilize enemies, then activate Blood Ode (Ultimate) to deal sustained damage and heal yourself. Her durability, while good for a mage, still requires smart engagement choices; avoid diving into too many enemies without backup.
In late-game teamfights, Alice can act as a frontline mage. Use Flowing Blood to dive into the enemy backline, targeting vulnerable damage dealers. Immediately activate Blood Ode and use Blood Awe to lock down key targets. Your goal is to stay in the middle of the enemy formation, continuously draining their health and sustaining yourself. Mana management remains crucial throughout all stages of the game; despite items like Demon Boots, avoid spamming skills unnecessarily to ensure you have mana for crucial teamfights.